The ASIO drivers are the best drivers to use.
How to configure Focusrite Saffire 6 ASIO driver in Ableton 10.
Select the ASIO driver type in Ableton Options | Preferences | Audio.
To avoid poor sound quality due to re-sampling ensure the in/out sample rate in Ableton matches the default format in the Windows 10 Sound Settings | Device Properties | Additional Device Settings | Advanced.
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Ableton Options | Preferences | Audio |
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Windows 10 Sound Settings |
If you want multiple applications to be able to use the Saffire at the same time you need to ensure Exlusive mode is not enabled in the Windows 10 Sound Settings | Additional Device Settings | Advanced.
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Additional Device Settings | Advanced |
NB The Live manual states the buffer size should be set to a multiple of 2 e.g. 512
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